Planar cell polarity (PCP)‐signaling and associated tissue polarization are evolutionarily conserved. A well documented feature of PCP‐signaling in vertebrates is its link to centriole/cilia positioning, although the relationship of PCP and ciliogenesis is still debated. A recent report in Drosophila established that Frizzled (Fz)‐PCP core signaling has an instructive input to polarized centriole positioning in non‐ciliated Drosophila wing epithelia as a PCP read‐out. Here, we review the impact of this observation in the context of recent descriptions of the relationship(s) of (...) core Fz‐PCP signaling and cilia/centriole positioning in epithelial and non‐epithelial cells. All existing data are consistent with a model where Fz‐PCP signaling functions upstream of centriole/cilia positioning, independent of ciliogenesis. The combined data sets indicate that the Fz‐Dsh PCP complex is instructive for centriole/ciliary positioning via an actin‐based mechanism. Thereby, centriole/cilia/centrosome positioning can be considered an evolutionarily conserved readout and common downstream effect of PCP‐signaling from flies to mammals. (shrink)

Among the elements which have gradually been complicating the countless representations of the Virgin Mary throughout history, this paper seeks to highlight and interpret conceptually one of special doctrinal significance in some Marian images during the fourteenth and fifteenth centuries: the temple, in whose interior some artists place some actual or symbolic episodes of Mary, from her birth or her Annunciation to the Sacra Conversazione, to give a few examples. Even though at first sight it looks as a mere scenographic (...) or ornamental ingredient, without iconographic value, this precise shape of temple reveals in fact some profound Mariological and Christological meanings. In that order of ideas, this essay is based on a double methodological strategy: first and foremost, to analyze some Marian images which include in the aforementioned period the shape of a temple, in order to see what kind of role such a religious building plays in them; secondly, to discover the relevant keys for interpreting such images, by analyzing some specific texts of the Church Fathers and medieval theologians who identify with Mary the figure of the «temple of God». For this reason, after a brief introduction to the problem, the present study is structured into three main parts inextricably intertwined: in the first we comparatively analyze twelve Marian paintings of the fourteenth and fifteenth centuries in which the Virgin appears inside a temple; in the second we explain the many exegesis that, in a consistent and strong patristic and theological tradition, identify the analogy of the templum Dei directly with the Virgin Mary, or indirectly with the Christ’s human body conceived in her womb; on the basis of this double analysis of images and exegetical writings, the third part of the paper states as a synthetic conclusion that the artistic representation of a temple or a church building in some Marian images of this period offers a compelling plastic metaphor of Mary and, ultimately, of her virginal divine motherhood. (shrink)

La tesis mariológica de la conceptio per aurem, según la cual la Virgen María habría concebido a Jesucristo por el oído en el momento de escuchar del ángel el mensaje celestial anunciándole que, sin perder su virginidad, sería madre del Hijo de Dios encarnado, ha merecido hasta ahora muy pocos estudios académicos rigurosamente fundados en fuentes primarias. De hecho, en la literatura especializada son muy escasas las referencias a tal teoría y, cuando algún estudioso la evoca, casi siempre se contenta (...) con aludir a ella, sin aportar pruebas documentales. Sin embargo, tal como lo revelan las nueve pinturas italianas aquí analizadas, esa teoría fue ilustrada mediante sutiles metáforas visuales en muchas obras pictóricas medievales, las cuales se inspiraron en una sólida tradición literaria. Además una pléyade de Padres de la Iglesia y teólogos medievales testimonia, mediante afirmaciones explícitas, que semejante teoría gozó de notable aceptación entre los maestros del pensamiento cristiano. Basándose en numerosos textos patrísticos y teológicos, este artículo intenta dos objetivos esenciales: exponer, ante todo, las distintas formulaciones teóricas propuestas por esos pensadores; y además, tratar de poner en luz los significados dogmáticos que subyacen bajo esa sorprendente tesis. (shrink)

A partir de la exégesis de Marcos 8,27, el autor se plantea y responde a la pregunta sobre el significado de Cristo para el hombre de hoy y llega a la siguiente conclusión: Cristo, para el hombre de hoy, como para el hombre de su tiempo, y como para el hombre del próximo milenio, es siempre el mismo, porque es el único camino que conduce al Padre, la única y última revelación del misterio del amor de Dios: es la verdad (...) absoluta que ilumina y da sentido a nuestro camino por este mundo: finalmente, es la vida verdadera, la vida completa y feliz, ya que en el encuentro con él y a través de él nos adentraremos en la vida divina del Padre, del Hijo y del Espíritu Santo. (shrink)

San Agustín hace posible el uso de la retórica en la predicación cristiana, tanto en la teoría como en la práctica. Los mismos recursos, pero usados de otra manera. Esto puede analizarse mediante el uso y función de los "signa" en su propia predicación. Los "In Ioannis euangelium tractatus" proporcionan una base sólida para el estudio de los "signa", según los utiliza Agustín.

Un análisis ameno e inteligente sobre los testimonios de los grandes pensadores del progreso: E. Fromm, F. Nietzsche, K. Popper, E. Morin, C.G. Jung, M. Ferguson, A. Finkielkraut, Ortega y Gasset, entre otros.

In this article, the dominant legitimating discursive strategies around the ever-increasing labour demands and ever-declining standards of safety and well-being at work in Spain are analysed through the lens of Boltanski and Thévenot’s (2006) view of the transformation of capitalism. A qualitative methodology based on semi-structured interviews is used. Results show that the justificatory arguments most commonly put forward by managers and experts are the logic of supply and demand, and values related to flexibility, resilience and adaptability to change. In (...) contrast, the stability and protection established in the twentieth century are widely cherished values, particularly among union representatives and some human resources specialists. We found that discourse practices map two specific legitimating categories (market values and a projects orientation), and one critical category (Civic World), but the critical category has no practical impact, as the predominant feeling is resignation. Our research describes the common attitudes to legitimacy in the job market and points to a deep discontent in some of its key agents. (shrink)

De manera poco académica, comienzo mi última lección en este acto con que me honra la Facultad, haciéndome eco de una acusación frecuente: algunos de las nuevas promociones de presbíteros –dicen presbíteros baqueteados por la vida– tienden a una comprensión y práctica de la liturgia en clave preferentemente ceremonial, desentendiéndose de la pastoral social; de ser esto cierto, sería una vuelta atrás, tan atrás que ya fue rechazada en su día por el Papa Pío XII en la única encíclica enteramente (...) litúrgica conocida hasta hoy, la Mediator Dei, fechada el 20 de noviembre de 1947. (shrink)

Hasta mediado s del siglo pasado, el tema que nos ocupa, la presencia de Cristo en los sacramentos, se resumía y concentraba, po r no deci r que se agotaba, en la presencia real eucanstica. O sea el concept o 'presencia' de Cristo se reservaba en la practica únicamente para su realización máxima en la Eucaristía; era la presencia real somática la que absorbía cualquier otra forma de presencia sacramental, que en todo caso quedaba en la sombra. Subrayo lo de (...) presencia sacramental, porque obviamente la presencia divina llenándolo todo, abarcando el cosmo s y la historia, no era desconocida Po r lo que a mi se m e alcanza, la primera vez que en un documento eclesiástico se hace explícita referencia a la presencia de Cristo en los sacramentos es precisamente en la única encíclica enteramente consagrada a la liturgia que hasta hoy conocemos : la Mediator Dei promulgada por Pío XII el 20 de noviembre de 1947. La doctrina aquí propuesta ha tenido tal aceptación o recepción que pertenece ya, podríamos decir, al tesoro de la Tradición. (shrink)

De entre el ingente corpus teórico del pensador franciscano Buenaventura de Bagnoregio, hemos focalizado aquí nuestra atención sobre el libro titulado Itinerarium mentis in Deum (1259), porque en él nuestro autor condensa el núcleo esencial de su peculiar Estética. Restringiendo aún más el enfoque investigador, en el presente artículo nos limitamos a analizar la primera de las tres fases o niveles en que Buenaventura estructura su Estética, a saber, la fase que podríamos denominar Estética inmanente. En ella, según el autor, (...) el ser humano puede llegar al conocimiento de Dios, si considera los seres materiales como vestigios e imágenes bellas que reflejan visiblemente la invisible belleza divina. En la segunda parte de nuestro artículo, intentamos poner en evidencia algunas tesis de filósofos precedentes que parecen haber inspirado casi con certeza a San Buenaventura en los enunciados básicos de su Estética inmanente. (shrink)

This paper seeks to highlight the various interpretations that, before the Second Council of Constantinople, many Latin Church Fathers gave on several metaphorical expressions, such as “God’s temple,” “sanctuary,” “tabernacle,” “ark,” and other similar terms referring to spaces or containers reserved for deity. To address this issue, the author of this article structures his methodology on three strategies: the first consists in a profound tracking in Patristic and theological sources to detect some relevant statements by conspicuous Christian masters on the (...) subject; through the second, he analyzes intra-textually each found Patristic assertions to decipher the doctrinal interpretation that every Christian writer brings about such metaphors; by the third methodological strategy, he intertextually relates all these texts, and authors through a comparative analysis to highlight their possible concordances or discrepan- cies. Resumen Este artículo busca resaltar las diversas interpretaciones que, antes del Segundo Concilio de Constantinopla, muchos Padres de la Iglesia Latina dieron sobre varias expresiones metafóricas, como “templo de Dios”, “santuario”, “tabernáculo”, “arca”,y otros términos similares referidos a espacios o contenedores reservados a la divinidad. Para abordar este tema, el autor del presente artículo estructura su metodología en tres estrategias fundamentales: el primer paso consiste en un seguimiento sistemático y profundo en fuentes patrísticas y teológicas para detectar declaraciones relevantes de conspicuos maestros de la doctrina cristiana sobre el tema; a través del segundo procedimiento, analiza intra- textualmente cada una de las afirmaciones patrísticas encontradas para descifrar la interpretación doctrinal que cada escritor cristiano aporta sobre tales metáforas; mediante la tercera y conclusiva estra tegia metodológica, el autor relaciona intertextualmente todos estos textos y pensadores a través de un análisis comparativo para resaltar sus posibles concordias o discrepancias. (shrink)

Background Safeguarding the right to die according to the principles of autonomy and freedom of each person has become more important in the last decade, therefore increasing regulation of Euthanasia and Medically Assisted Suicide (MAS). Aims To learn the opinions that the nurses of the autonomous region of Madrid have regarding Euthanasia and Medically Assisted Suicide. Research design Cross-sectional descriptive study. Participants and research context All registered nurses in Madrid. The study was done by means of a self-completed anonymous questionnaire. (...) The variables studied were social-demographic, giving opinions about Euthanasia and MAS. Ethical considerations Each participant was assured maximum confidentiality and anonymity, ensuring the ethical principles set out in the Declaration of Helsinki, as well as in the Organic Law 3/2018, on Personal Data Protection and guarantee of digital rights. Findings A total of 489 nurses answered the questionnaire. In total, 75.7% of the nurses confirmed that Euthanasia should be regulated in Spain. 66.3% indicated that information on Euthanasia should be provided jointly by doctors and nurses, and 42.3% considered that it could be applied by both medical and nursing professionals. A total of 87.2% advocated the participation of nurses in health policy, influencing the drafting of the law. In the face of possible regulation, 35% would request Conscientious Objection, being closely related to their religious beliefs. Discussion Different authors point out that nurses’ perceptions and attitudes towards Euthanasia are conditioned by different factors, such as religion, gender, poor palliative care, legality and the patient's right to die. Conclusion Nurses are positioned in favour of the regulation and practice of Euthanasia and MAS, depending on their age, years of experience, training, model of care and especially religious beliefs. (shrink)

Background: Depressive disorder is one of the main health problems worldwide. Many risk factors have been associated with this pathology. However, while the association between risks factors and adult depression is well established, the mechanisms behind its impact remains poorly understood. A possible, yet untested explanation is the mediating impact of levels of personality functioning, i.e., impairments with regard to self and interpersonal.Method: Around 162 patients were assessed at the beginning of their therapy, with regard to risk factors, such as (...) sociodemographic, physical, hereditary, and adverse childhood experiences. Depressive symptoms and personality functioning were also measured. Associations between the related variables as well as other possible covariates were examined by means of zero-order correlations and bootstrapping-based mediation analysis.Results: Of all the risk factors taken into account, level of education and physical illness were associated with depression. On the other hand, the most significant predictor of depressive symptomatology was ACE, and this relationship was mediated by personality functioning. This indicates that patients presenting adverse childhood experiences are more likely to develop deficiencies in personality functioning, which in turn increases their likelihood of developing depressive symptomatology.Conclusion: These results reaffirm the importance of incorporating risk and vulnerability factors such as personality functioning in understanding depression. (shrink)

A inicio de los años 90 la sociedad cubana se enfrentaba a un proceso de profundas transformaciones internas como consecuencia de los cambios en la esfera de las relaciones internacionales, el recrudecimiento del bloqueo de Estados Unidos y la necesidad de insertarse en la nueva dinámica de las relaciones económicas mundiales después de desaparecida la URSS y el socialismo este-europeo. Todo ello tuvo un importante impacto en los valores de la sociedad cubana, especialmente en los jóvenes. En razón de ello, (...) la Asamblea nacional del Poder Popular convocó a una audiencia pública sobre la formación de valores en las nuevas generaciones, llevada a cabo los días 24 y 25 de abril de 1995. Este libro recoge las más importantes intervenciones presentadas desde diversos planos de análisis: filosófico (José Ramón Fabelo Corzo), histórico (Cintio Vitier), sociológico (María Isabel Domínguez), psicológico (Fernando González) y pedagógico (Gilberto García Batista). (shrink)

The primary goal of the present research was to determine the order of swimmers on a mixed relay team that would ensure the best performance in the Fédération Internationale de Natation World Championships held in Kazan, Budapest, and Gwangju. The data were obtained from database websites for the 4 × 100 m freestyle and 4 × 100 m medley official results,1 including 660 records from 188 entries of finals and 472 preliminary events. The results showed that the fastest swimmers were (...) located primarily in the first or second positions of the freestyle relay. The most successful gender strategy for the 4 × 100 m freestyle and for the 4 × 100 m medley relays was the order male-male-female-female, although no statistical differences were found for the medley relays. In the 4 × 100 m freestyle, the second and third relay legs had a statistical effect on the total relay time, whereas in the 4 × 100 m medley, all four relay legs had a statistical effect on the final performance, the weight of the four strokes being different in heats with respect to the final round. Also, a later position of the first female swimmer or the consecutive position of two female swimmers in the team order significantly affected the relay performance in specific events. Mixed relay events appeared to present specific strategies in comparison to traditional male- or female-only relay lineups. (shrink)

Este trabajo tiene como objetivo caracterizar el proceso de evaluación del aprendizaje del contenido estadístico en la carrera de Medicina. Los resultados obtenidos evidencian que el nivel de asimilación alcanzado por los estudiantes en muchas ocasiones es el reproductivo, lo que refleja la necesidad de seguir profundizando en los estudios de esta problemática. Issues related to the learning evaluation have been present throughout the teaching learning process history. The following research aims at characterizing the learning process of evaluation of the (...) statistical content in medicine. Results demonstrate that the assimilation level reached by students, on many occasions, is the reproductive one, as a need to deepen on methodology of the design of the system of evaluation of the statistical content learning in medicine. (shrink)

Forgiveness seeking after a relational transgression is an important aspect of relational repair from an interpersonal perspective, although it has received much less attention than the process of granting forgiveness. This research focuses on the victim's perspective of the transgressor's behaviors and how they are related to forgiveness and offense characteristics. This paper proposes a multidimensional concept of seeking forgiveness that includes four dimensions: apologies, restorative action, relational caring behaviors, and diverting behaviors. A questionnaire for assessing these dimensions was developed (...) and tested with a general population sample of 450 subjects. Participants recalled a specific offense and then answered a questionnaire about the perceived usefulness of different forgiveness-seeking behaviors, a forgiveness inventory, and several questions regarding the characteristics of the offense. Our results support the four-factor structure of the questionnaire. As the perceived intentionality of the offense increases, behaviors that are directly related to the transgression, such as apologies and restorative actions, are experienced as less useful for forgiveness. The more hurtful the offense, the less useful the diverting behaviors are. Behavior such as apologies and restorative action are related to a lower motivation for revenge, while all forgiveness-seeking behaviors are related to an increase in feelings of benevolence toward the offender. (shrink)

Emotional disorder symptoms are highly prevalent and a common cause of disability among children and adolescents. Screening and early detection are needed to identify those who need help and to improve treatment outcomes. Nowadays, especially with the arrival of the COVID-19 outbreak, assessment is increasingly conducted online, resulting in the need for brief online screening measures. The aim of the current study was to examine the reliability and different sources of validity evidence of a new web-based screening questionnaire for emotional (...) disorder symptoms, the DetectaWeb-Distress Scale, which assesses mood, anxiety, obsessive–compulsive disorder, post-traumatic stress disorder, suicidality, and global distress. A total of 1,499 participants completed the DetectaWeb-Distress Scale and specific questionnaires for emotional disorder symptoms, suicidal behaviors, and well-being through a web-based survey. Results indicated that a structural model of 10 correlated factors fits reasonably better in comparison to the remaining models; measurement invariance for age and gender; good internal consistency ; and significant positive correlation with other measures of anxiety, depression, PTSD, or distress, and negative correlation with well-being measures, displaying support for convergent-discriminant validity. We also found that girls scored higher than boys on most of the subscales, and children had higher scores for social anxiety, specific phobia, panic disorder, and obsessive–compulsive symptoms, whereas adolescents scored higher on depressive symptoms, suicidality, and generalized anxiety, but the effect sizes were small to medium for all comparisons. The DetectaWeb-Distress Scale is a valid, innovative, and useful online tool for the screening and evaluation of preventive programs for mental health in children and adolescents. (shrink)

Aberrations introduced by the atmospheric turbulence in large telescopes are compensated using adaptive optics systems, where the use of deformable mirrors and multiple sensors relies on complex control systems. Recently, the development of larger scales of telescopes as the E-ELT or TMT has created a computational challenge due to the increasing complexity of the new adaptive optics systems. The Complex Atmospheric Reconstructor based on Machine Learning is an algorithm based on artificial neural networks, designed to compensate the atmospheric turbulence. During (...) recent years, the use of GPUs has been proved to be a great solution to speed up the learning process of neural networks, and different frameworks have been created to ease their development. The implementation of CARMEN in different Multi-GPU frameworks is presented in this paper, along with its development in a language originally developed for GPU, like CUDA. This implementation offers the best response for all the presented cases, although its advantage of using more than one GPU occurs only in large networks. (shrink)

This work focuses on the application of machine learning techniques to assist the clinicians in the administration of analgesic drug during general anaesthesia. Specifically, the main objective is to propose the basis of an intelligent system capable of making decisions to guide the opioid dose changes based on a new nociception monitor, the analgesia nociception index. Clinical data were obtained from 15 patients undergoing cholecystectomy surgery. By means of an off-line study, machine learning techniques were applied to analyse the possible (...) relationship between the analgesic dose changes performed by the physician due to the hemodynamic activity of the patients and the evolution of the ANI. After training different classifiers and testing the results under cross validation, a preliminary relationship between the evolution of ANI and the dosage of remifentanil was found. These results evidence the potential of the ANI as a promising index to guide the infusion of analgesia. (shrink)

The structural and dynamic dimensions of complexity of the Internet are connected with epistemological and ontological factors, which are the main modes of complexity of the sciences of the Internet. These dimensions and modes of complexity are relevant for the communication sciences, because this field is one of the most important areas of development of this network of networks. Philosophy needs to address the problems of complexity that arise from the sciences of the Internet that have consequences for the communication (...) sciences. This article deals with these problems through a new approach in the philosophy of communication sciences based on the sciences of the artificial conceived as sciences of design. (shrink)

The objective of this study is to determine the contribution made by knowledge of letters, phonological awareness, phonological memory, and alphanumeric and non-alphanumeric rapid automatized naming at the ages of six and seven to the ability of Spanish children to read words at 7 years of age. A total of 116 Spanish-speaking school children took part in the study, from schools located in an average socio-cultural setting, without special educational needs. The reading ability of these pupils was evaluated at the (...) age of seven, and cognitive variables were assessed at 6 and 7 years of age. Descriptive-exploratory analyses, bivariate analyses, and multivariate regressions were performed. The results show that cognitive variables measured at these ages contribute differently to the ability to read words at 7 years of age. Rapid naming does not seem to influence word reading; knowledge of letters no longer influences word reading as children grow older; and phonological awareness and phonological memory maintain their contribution to the explanation of word reading. These results indicate that reading in Spanish depends on different cognitive variables and that this relationship varies according to age. The findings have key educational implications in terms of teaching reading skills and the prevention of specific learning difficulties in Spanish Primary Education. (shrink)

The following dilemma is discussed: On the one hand, the growing impact of Technology of communication and information (ICT) in everyday habits seems to influence the dynamics of public opinion by reinforcing irrational beliefs and creating the impression that the autonomy of people’s opinion and decisions is just a myth. On the other hand, people seem to act most of the time, under the normal circumstances of daily life, in a rational way, as if their habitual actions result from relatively (...) autonomous decisions. A way out of this dilemma is suggested with the hypothesis that people can be rational most of the time, but nevertheless have their opinions influenced by insufficient, distorted information, or by previously acquired emotional dispositions. This hypothesis, in turn, is going to be scrutinized by considering, from a philosophical-interdisciplinary perspective, the role of rational choices in the dynamics of autonomous opinion. With illustrations of diagrams, we claim that the qualitative Complex Systems paradigm might help us to understand the possible role of emotional dispositions in the dynamics of autonomous opinion formation. (shrink)

The objective of this study is to analyze the relationship between views and social interaction generated by YouTuber videos in Spanish. A quali-quantitative analysis is conducted on a sample of 100 videos, 10 YouTube channels, 997 minutes of video, with 116,934,321 views, 12,297,021 likes/dislikes, and 1,041,191 comments on YT, 306,000 retweets/favorites on TW and 140,852 comments, shares, and reactions on FB. The existence of social media tools on YouTube does not in itself guarantee interaction by users who prefer to watch (...) videos and adopt a passive attitude. In this analysis, we propose a social interaction indicator that takes into account the total number of social media reactions made on social networks and the age of the video. Cultivating realistic conversation and interaction on platforms with audiences numbering in the millions represents a serious challenge for YouTubers. (shrink)

En este artículo se pretende poner de manifiesto las restricciones impuestas por el Estado español a la libertad de movimiento. Una vez descritas estas restricciones en las tres primeras olas de la pandemia de la Covid-19, se reflexiona sobre los posibles excesos del gobierno aumentando su control sobre una ciudadanía preocupada y con temor hacia la pandemia. Sin embargo, existe una consecuencia inesperada en las actitudes políticas de las personas: una reducción de las preferencias hacia la democracia, a favor del (...) autoritarismo. (shrink)